Basic Science
Exploration of the fundamental biological and molecular mechanisms underlying lipedema, including adipocyte dysfunction, inflammatory pathways, and extracellular matrix alterations.

Epidemiology of Lipedema
Analysis of the global prevalence and incidence of lipedema, with a focus on genetic predisposition, environmental influences, and ethnic variations in disease manifestation.

Pathophysiology
Investigation of the mechanisms leading to the pathological expansion of subcutaneous fat, chronic inflammation, and progressive fibrosis, as well as the role of hormonal and vascular factors.

Metabolic Aspects
Examination of metabolic dysregulations associated with lipedema, including lipid metabolism, mitochondrial function, and systemic metabolic impairments.

Lipedema and Pain
Understanding the pathogenesis of pain in lipedema, including neuroinflammatory mechanisms, sensory nerve involvement, and the impact on quality of life.

Lipedema and Insulin Resistance
Evaluation of the association between lipedema and insulin resistance, its implications for metabolic syndrome, and potential therapeutic interventions.

Lipedema and Obesity
Differentiation between lipedema and obesity, including diagnostic criteria, metabolic differences, and shared pathophysiological features.

Clinical Diagnosis
Standardized clinical criteria for diagnosing lipedema, emphasizing differential diagnosis and early detection strategies.

Laboratory and Clinical Investigations
Emerging biomarkers and laboratory assessments for lipedema, along with clinical parameters for disease progression monitoring.

Conservative Treatment
Evidence-based non-surgical management approaches, including physical therapy, manual lymphatic drainage, compression therapy, and pharmacological interventions.

Nutritional Aspects in Lipedema
Role of diet and lifestyle modifications in managing lipedema symptoms, with a focus on anti-inflammatory and metabolic interventions.

Surgical Treatment
Advances in surgical techniques such as liposuction and excisional procedures for lipedema, including patient selection criteria and long-term outcomes.

Lipedema and the Lymphatic System
Interaction between lipedema and lymphatic dysfunction, exploring potential links to lymphedema and chronic fluid imbalance.

Lipedema and the Venous System
Investigation of venous insufficiency in lipedema patients, including its contribution to disease progression and therapeutic implications.

Ongoing Research Strands
Latest research developments in lipedema, encompassing genetic studies, novel biomarkers, and innovative treatment modalities.

Role of Patient Associations in Favor of Lipedema
The impact of patient advocacy groups in raising awareness, promoting early diagnosis, influencing healthcare policies, and supporting research initiatives.